A Spatial Place to B
About Us
Advancing immunology through innovation
The Engblom Lab is a medical research laboratory located in Stockholm, Sweden, part of the Karolinska Institutet and SciLifeLab. Headed by immunology and spatial transcriptomics expert Camilla Engblom, the lab focuses on understanding fundamental mechanisms of immune cell dynamics during health and disease with a particular emphasis on cancer.
The team employs a spatial transcriptomics-based approach co-developed by Dr Engblom, known as Spatial VDJ, to investigate and spatially resolve immune cell receptors and lineage trajectories in tissues. Particularly interested in B cells and the B cell-derived antibody producing cells, the Engblom Lab couples spatial technologies with other experimental tools to link clonal dynamics with antibody specificities. Since its inception in 2023, the Engblom Lab has through its contributions to the field of spatial immunobiology attracted researchers and collaborators keen to advance the understanding of immune responses.
Some Current Research Areas
Spatial Immunity in Inflammation:
Mapping clones in cancer
Our aim is to uncover functionally important regulators of tissue-infiltrating B and plasma cell clones by mechanistical dissection.
Unravelling antigens and antibodies
We are functionally evaluating and screening for antigen specificity for tissue-expanded BCR sequences.
Identifying niches
To build maps of antigen-specific B cell niches our group focuses on using existing and new tools to adapt current computational methods available for Spatial VDJ to define genes.